Med1tm1Jkr
Targeted Allele Detail
|
|
| Symbol: |
Med1tm1Jkr |
| Name: |
mediator complex subunit 1; targeted mutation 1, Janardan K Reddy |
| MGI ID: |
MGI:1861123 |
| Synonyms: |
PBP- |
| Gene: |
Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
|
| Alliance: |
Med1tm1Jkr page
|
|
Histological and ultrastructural alterations in Med1tm1Jkr/Med1tm1Jkr placenta
Show the 5 phenotype image(s) involving this allele.
|
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:62272
|
| Parent Cell Line: |
HM-1 (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: Exons 12-14 were disrupted with a PGK-neo cassette via homologous recombination resulting in the loss of 2 LXXLL motifs. Northern and Western blot analysis of fibroblasts from homozygous mutant embryos showed absence of gene transcript and protein product.
(J:62272)
|
| Inheritance: |
|
Recessive |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Med1 Mutation: |
83 strains or lines available
|
|
| Original: |
J:62272 Zhu Y, et al., Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem. 2000 May 19;275(20):14779-82 |
| All: |
2 reference(s) |
|
Analysis Tools
