Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Il1r1tm1Imx
Name:	interleukin 1 receptor, type I; targeted mutation 1, Immunex Research and Development Corporation
MGI ID:	MGI:1861112
Synonyms:	IL-1R-, IL-1R1-, Il1r1tm1jmx, IL-1RI KO, Il1rtm1Imx, IL-R1-, RIko
Gene:	Il1r1  Location: Chr1:40264240-40356417 bp, + strand  Genetic Position: Chr1, 18.81 cM
Alliance:	Il1r1tm1Imx page

Germline Transmission:	Earliest citation of germline transmission: J:43088
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced two exons of the gene, which encode amino acids 4 - 225 of the mature protein. (J:43088)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Il1r1tm1Imx

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il1r1 Mutation:	39 strains or lines available

Original:	J:43088 Glaccum MB, et al., Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol. 1997 Oct 1;159(7):3364-71
All:	401 reference(s)