Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ltbtm1Flv
Name:	lymphotoxin B; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:1860955
Synonyms:	LT beta-, LTbeta-
Gene:	Ltb  Location: Chr17:35413483-35415281 bp, + strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Ltbtm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:39746
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 0.7 kb fragment of the gene, truncating the coding sequence at codon 153. Northern blots of total RNA from splenocytes from homozygous mutant mice showed an absence of mRNA for the targeted gene. (J:39746, J:95222)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltb Mutation:	18 strains or lines available

Original:	J:39746 Koni PA, et al., Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 1997 Apr;6(4):491-500
All:	33 reference(s)