Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrbtm1Olc
Name:	thyroid hormone receptor beta; targeted mutation 1, Olivier Chassande
MGI ID:	MGI:1860407
Synonyms:	TRbeta-, TRBetaKO
Gene:	Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Thrbtm1Olc page

Germline Transmission:	Earliest citation of germline transmission: J:52829
Parent Cell Line:	ENS (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A cassette containing both a lacZ coding sequence and a neomycin resistance gene was used to replace exons 4 and 5 which code for the DNA binding domain. This insertion inactivates both the beta1 and beta2 isoforms. RT-PCR was used to demonstrate a lack of mRNA in homozygous mutant animals. (J:52829)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:	39 strains or lines available

Original:	J:52829 Gauthier K, et al., Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J. 1999 Feb 1;18(3):623-31
All:	33 reference(s)