Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnp1tm1Mlm
Name:	transition protein 1; targeted mutation 1, Marvin L Meistrich
MGI ID:	MGI:1859961
Synonyms:	Tnp1-, Tnp1-null
Gene:	Tnp1  Location: Chr1:73054233-73055058 bp, - strand  Genetic Position: Chr1, 36.94 cM
Alliance:	Tnp1tm1Mlm page

Germline Transmission:	Earliest citation of germline transmission: J:61941
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire gene was replaced with a neomycin cassette, which was inserted in an antisense orientation. Tnp1 protein was not detectable in extracts of testicular homogenates from homozygous mutant mice. (J:61941)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnp1 Mutation:	4 strains or lines available

Original:	J:61941 Yu YE, et al., Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4683-8
All:	6 reference(s)