Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Tnfrsf4tm1Nik Name: tumor necrosis factor receptor superfamily, member 4; targeted mutation 1, Nigel Killeen MGI ID: MGI:1859871 Synonyms: CD134-, OX40-, OX40 KO Gene: Tnfrsf4  Location: Chr4:156098300-156101069 bp, + strand  Genetic Position: Chr4, 87.68 cM Alliance: Tnfrsf4tm1Nik page

Lung inflammatory infiltrates, goblet cell hyperplasia, and mucus production are reduced in Tnfrsf4tm1Nik/Tnfrsf4tm1Nik mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58979
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette was used to replace four exons, which code for the first 143 amino acids of the protein. Activated T cells from homozygous mutant animals lacked expression of Tnfrsf4 as detected by flow cytometry with the OX86 mAb as well as a soluable ligand fusion protein. (J:58979)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf4 Mutation:	33 strains or lines available

Original:	J:58979 Pippig SD, et al., Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 1999 Dec 15;163(12):6520-9
All:	46 reference(s)