Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Fancctm1Mgo
Name:	Fanconi anemia, complementation group C; targeted mutation 1, Markus Grompe
MGI ID:	MGI:1858041
Synonyms:	facdeltaexon 9
Gene:	Fancc  Location: Chr13:63452519-63645126 bp, - strand  Genetic Position: Chr13, 32.8 cM
Alliance:	Fancctm1Mgo page

Germline Transmission:	Earliest citation of germline transmission: J:61512
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic DNA fragment containing exon 9. RT-PCR analysis demonstrated that an abnormal transcript lacking only exon 9 was produced from this allele; however, no functional protein can be expressed from this mutant transcript. (J:61512)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Fancctm1Mgo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancc Mutation:	68 strains or lines available

Original:	J:61512 Whitney MA, et al., Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood. 1996 Jul 1;88(1):49-58
All:	13 reference(s)