Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou3f4tm1Cren
Name:	POU domain, class 3, transcription factor 4; targeted mutation 1, Bryan Crenshaw III
MGI ID:	MGI:1857990
Synonyms:	Brn4-
Gene:	Pou3f4  Location: ChrX:109857886-109860813 bp, + strand  Genetic Position: ChrX, 48.2 cM
Alliance:	Pou3f4tm1Cren page

Germline Transmission:	Earliest citation of germline transmission: J:56294
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ reporter gene and a PGK-neomycin resistance cassette replaced the entire intronless coding region and a small region of 3'-flanking sequences. (J:56294)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f4 Mutation:	3 strains or lines available

Original:	J:56294 Phippard D, et al., Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear. J Neurosci. 1999 Jul 15;19(14):5980-9
All:	6 reference(s)