Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp53tm1Mlh
Name:	transformation related protein 53; targeted mutation 1, Martin L Hooper
MGI ID:	MGI:1857989
Synonyms:	p53-
Gene:	Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance:	Trp53tm1Mlh page

Germline Transmission:	Earliest citation of germline transmission: J:60008
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of exons 2-6 with a neomycin cassette. (J:60008)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Trp53tm1Mlh

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	232 strains or lines available

Original:	J:60008 Clarke AR, et al., Thymocyte apoptosis induced by p53-dependent and independent pathways [see comments]. Nature. 1993 Apr 29;362(6423):849-52
All:	29 reference(s)