Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Atp2b2tm1Ges Name: ATPase, Ca++ transporting, plasma membrane 2; targeted mutation 1, Gary E Shull MGI ID: MGI:1857876 Synonyms: Pmca2 - Gene: Atp2b2  Location: Chr6:113720803-114019574 bp, - strand  Genetic Position: Chr6, 52.85 cM Alliance: Atp2b2tm1Ges page

Atp2b2tm1Ges/Atp2b2tm1Ges mice exhibit an unsteady gait and difficulty in maintaining balance Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:48863
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 19, which encodes transmembrane domains essential for transport activity. Northern blot analysis demonstrated that no detectable transcript was produced from this allele in brain of homozygous mice. (J:48863)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Atp2b2 Mutation:	66 strains or lines available

Original:	J:48863 Kozel PJ, et al., Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem. 1998 Jul 24;273(30):18693-6
All:	15 reference(s)