Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ntrk2tm1Bbd
Name:	neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Mariano Barbacid
MGI ID:	MGI:1857814
Synonyms:	gp145trkB, trkB-, trkBnull, trkBTK(-)
Gene:	Ntrk2  Location: Chr13:58954383-59281784 bp, + strand  Genetic Position: Chr13, 31.2 cM
Alliance:	Ntrk2tm1Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:56847
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Gene disruption by insertion of a PGK-neomycin cassette into exon K2, which encodes subdomains III - V of the tyrosine kinase domain. (J:56847)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ntrk2 Mutation:	66 strains or lines available

Original:	J:56847 Klein R, et al., Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 1993 Oct 8;75(1):113-22
All:	61 reference(s)