Cation concentrations would be elevated in macrophages from mice carrying mutations that alter Slc11a1 transport function, i.e. the Slc11a1^s allele, rendering susceptibility to infection. This model is supported by the observation that mice normally resistant to Mycobacterium avium infection loose their advantage over Slc11a1^s mice when exposed to an excess of iron.(J:50686)

The point mutation associated with the susceptible phenotype was initially identified as Gly105Arg. In J:25627 (1995), the authors report that the full-length mRNA encodes a protein 64 amino acids longer at the N-terminus than previously reported, including two additional transmembrane domains. Therefore, the actual amino acid substitution is Gly169Arg. The nucleotides cannot be assigned numbers because the gene contains no TATA or CAAT element and has multiple transcription initiation sites. (J:25627)

Strains carrying this allele include BALB/cJ, C57BL/6J, C57BL/10J, CE/J, DBA/1J, MOLF/Ei, NZW/LacJ, SWV. (J:4762, J:20139)