Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Adam17tm1Imx Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Immunex MGI ID: MGI:1857753 Synonyms: ADAM17deltaZn, ADAM17Zndelta, TACE-, tacedeltaZn Gene: Adam17  Location: Chr12:21373510-21423633 bp, - strand  Genetic Position: Chr12, 8.3 cM Alliance: Adam17tm1Imx page

Adam17tm1Imx/Adam17tm1Imx embryos develop internal hemorrhage Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:38527
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin cassette replaced a 1.2kb fragment of the gene, which encodes the zinc-binding domain. (J:38527)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	28 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:	62 strains or lines available

Original:	J:38527 Black RA, et al., A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997 Feb 20;385(6618):729-33
All:	42 reference(s)