Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Foxc2tm1Miu
Name:	forkhead box C2; targeted mutation 1, Naoyuki Miura
MGI ID:	MGI:1857740
Synonyms:	Mfh1-, MFH-1-
Gene:	Foxc2  Location: Chr8:121842910-121845634 bp, + strand  Genetic Position: Chr8, 70.33 cM
Alliance:	Foxc2tm1Miu page

Germline Transmission:	Earliest citation of germline transmission: J:55316
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the entire coding region of the gene. RT-PCR analysis on RNA derived from E11.5 homozygous embryos confirmed that no detectable transcript was produced from this allele. (J:55316)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	33 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxc2 Mutation:	15 strains or lines available

Original:	J:55316 Iida K, et al., Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development. 1997 Nov;124(22):4627-38
All:	15 reference(s)