Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Htttm1Szi
Name:	huntingtin; targeted mutation 1, Scott Zeitlin
MGI ID:	MGI:1857722
Synonyms:	Hdh-, Hdhprex1
Gene:	Htt  Location: Chr5:34919084-35069878 bp, + strand  Genetic Position: Chr5, 17.92 cM
Alliance:	Htttm1Szi page

Germline Transmission:	Earliest citation of germline transmission: J:29267
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 2.8 kb fragment of the gene, which included the 5' flanking sequence, the entire first exon, and 0.6 kb of the 3' flanking intron. (J:29267)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htt Mutation:	179 strains or lines available

Original:	J:29267 Zeitlin S, et al., Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet. 1995 Oct;11(2):155-63
All:	15 reference(s)