Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tgfb1tm1N Name: transforming growth factor, beta 1; targeted mutation 1, National Institutes of Health MGI ID: MGI:1857671 Synonyms: Tgfb1-, TGF-beta1- Gene: Tgfb1  Location: Chr7:25386427-25404502 bp, + strand  Genetic Position: Chr7, 13.98 cM Alliance: Tgfb1tm1N page

Histopathological analysis on lung and heart tissues of Tgfb1tm1N/Tgfb1tm1N mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:50848
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of the first exon and intron was replaced by a phosphoglycerate kinase-neomycin resistance gene. (J:18881, J:50848)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Tgfb1tm1N

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:	34 strains or lines available

Original:	J:50848 Kulkarni AB, et al., Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4
All:	73 reference(s)