Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pcgf2tm1Hko
Name:	polycomb group ring finger 2; targeted mutation 1, Haruhiko Koseki
MGI ID:	MGI:1857633
Synonyms:	mel-18-, mel18-
Gene:	Pcgf2  Location: Chr11:97579649-97591323 bp, - strand  Genetic Position: Chr11, 61.06 cM, cytoband C1-C3
Alliance:	Pcgf2tm1Hko page

Germline Transmission:	Earliest citation of germline transmission: J:33159
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 5, which contains the transcriptional initiation codon and encodes the RING finger domain. RNAse protection assays demonstrated that a truncated transcript is produced from this allele in homozygous mice, but the authors predict that no functional protein can be translated. (J:33159)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	342 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pcgf2 Mutation:	48 strains or lines available

Original:	J:33159 Akasaka T, et al., A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development. 1996 MAY;122(5):1513-1522
All:	19 reference(s)