Epor<tm1Cos> Targeted Allele Detail MGI Mouse (MGI:1857575)

Epor^tm1Cos
Targeted Allele Detail

Summary

Symbol:	Epor^tm1Cos
Name:	erythropoietin receptor; targeted mutation 1, Frank Costantini
MGI ID:	MGI:1857575
Gene:	Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
Alliance:	Epor^tm1Cos page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:31156
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing 6 of the 8 exons of the gene was replaced by a neomycin resistance cassette. (J:31156)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Epor Mutation:	25 strains or lines available

Notes

Since homozygotes die by E13.5, chimeras, in which homozygous mutant ES cells were injected into wild-type embryos, were used to analyze hematopoiesis in adults. Homozygous mutant cells fail to contribute to the red blood cell fraction of chimeric adults although they contribute extensively to the white cell fraction (J:31156).

References

Original:	J:31156 Lin CS, et al., Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
All:	5 reference(s)

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