Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1tm1Ts
Name:	insulin-like growth factor 1; targeted mutation 1, Timothy Stewart
MGI ID:	MGI:1857466
Synonyms:	IGF-I-
Gene:	Igf1  Location: Chr10:87694127-87772904 bp, + strand  Genetic Position: Chr10, 43.7 cM
Alliance:	Igf1tm1Ts page

Germline Transmission:	Earliest citation of germline transmission: J:16214
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 3 after codon 15. This mutation inserts multiple stop codons into all reading frames of the B chain of the encoded protein. RT-PCR analysis demonstrated that the transcript is undetectable in homozygous animals. (J:16214)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:	27 strains or lines available

Original:	J:16214 Powell-Braxton L, et al., IGF-I is required for normal embryonic growth in mice. Genes Dev. 1993 Dec;7(12B):2609-17
All:	29 reference(s)