Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Fshbtm1Zuk
Name:	follicle stimulating hormone beta; targeted mutation 1, Martin M Matzuk
MGI ID:	MGI:1857434
Synonyms:	FSHbeta-, FSHbetaKO, fshbm1
Gene:	Fshb  Location: Chr2:106886485-106890001 bp, - strand  Genetic Position: Chr2, 56.02 cM
Alliance:	Fshbtm1Zuk page

Germline Transmission:	Earliest citation of germline transmission: J:38099
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An HPRT minigene replaced a genomic fragment containing exons 1, 2 and part of 3. Northern blot analysis on RNA derived from pituitary of homozygous mice demonstrated that no detectable transcript was produced from thia allele. Radioimmunoasays on serum from homozygous mice confirmed that no functional protein was expressed from this allele. (J:38099)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

List all tumor models in MMHCdb carrying Fshbtm1Zuk

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fshb Mutation:	11 strains or lines available

Original:	J:38099 Kumar TR, et al., Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet. 1997 Feb;15(2):201-4
All:	31 reference(s)