Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2l2Gt(ROSA)41Sor
Name:	BCL2-like 2; gene trap ROSA 41, Philippe Soriano
MGI ID:	MGI:1857389
Synonyms:	Bcl2l2Gtrosa41, Bcl-w-, BclwGtrosa41
Gene:	Bcl2l2  Location: Chr14:55120900-55125691 bp, + strand  Genetic Position: Chr14, 27.98 cM
Alliance:	Bcl2l2Gt(ROSA)41Sor page

Mutant Cell Line:	ROSA41
Germline Transmission:	Earliest citation of germline transmission: J:46386
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: ROSABetagal   Mutation details: A ROSA Beta-gal provirus inserted into intron 2, 134 bp upstream of exon 3. RT-PCR analysis demonstrated that the transcript was absent in brain, salivary gland and testis of homozygous mice. Western blot analysis demonstrated an absence of the protein in brain and testes of homozygous mice. (J:46386) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select FHCRC-GT-ROSA41 CG465911 (MGI Seq Detail) 5' RACE Chr14:55120851-55121340 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 1 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l2 Mutation:	19 strains or lines available

Original:	J:46386 Ross AJ, et al., Testicular degeneration in Bclw-deficient mice [see comments]. Nat Genet. 1998 Mar;18(3):251-6
All:	14 reference(s)