Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rb1tm1Brd
Name:	RB transcriptional corepressor 1; targeted mutation 1, Allan Bradley
MGI ID:	MGI:1857339
Synonyms:	Rb-, Rb-1delta20
Gene:	Rb1  Location: Chr14:73430298-73563446 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Alliance:	Rb1tm1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:2516
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     Insertion of a neomycin cassette into exon 20. (J:2516) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Rb1tm1Brd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:	106 strains or lines available

Original:	J:2516 Lee EY, et al., Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]. Nature. 1992 Sep 24;359(6393):288-94
All:	19 reference(s)