Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ifngr1tm1Agt Name: interferon gamma receptor 1; targeted mutation 1, Michel Aguet MGI ID: MGI:1857286 Synonyms: G129, IFN-gamma R-, IFN-gammaR-, IFN-gammaR-, IFN-gamma R0, IFN-gammaR0, IFN-gammaR1-, IFN-gammaRalpha_, IFN-gamma-R KO, IFN-gammaR KO, IFNgammaR KO, Ifngr-, Ifngr1-, IFNgR KO, IFn type II receptor Gene: Ifngr1  Location: Chr10:19467697-19485977 bp, + strand  Genetic Position: Chr10, 8.49 cM Alliance: Ifngr1tm1Agt page

Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:63815
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. (J:61321, J:63815, J:96036) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

List all tumor models in MMHCdb carrying Ifngr1tm1Agt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 13 strains available      Cell Lines: 0 lines available
Carrying any Ifngr1 Mutation:	52 strains or lines available

Original:	J:63815 Huang S, et al., Immune response in mice that lack the interferon-gamma receptor [see comments]. Science. 1993 Mar 19;259(5102):1742-5
All:	610 reference(s)