Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Jak3tm1Ljb
Name:	Janus kinase 3; targeted mutation 1, Leslie J Berg
MGI ID:	MGI:1857276
Synonyms:	Jak-3-, Jak3-
Gene:	Jak3  Location: Chr8:72129027-72143221 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance:	Jak3tm1Ljb page

Germline Transmission:	Earliest citation of germline transmission: J:29722
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. (J:29722)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak3 Mutation:	84 strains or lines available

Original:	J:29722 Thomis DC, et al., Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3;270(5237):794-7
All:	35 reference(s)