Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptgs2tm1Jed
Name:	prostaglandin-endoperoxide synthase 2; targeted mutation 1, Joe E Dinchuk
MGI ID:	MGI:1857239
Synonyms:	Cox-2-, COX-2-, COX2-, Ptgs2-
Gene:	Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Alliance:	Ptgs2tm1Jed page

Germline Transmission:	Earliest citation of germline transmission: J:29974
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.8 kb genomic fragment containing exon 1 and the transcription and translation start sites was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from embryonic fibroblasts derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:29974)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

17 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptgs2tm1Jed

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:29974 Dinchuk JE, et al., Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995 Nov 23;378(6555):406-9
All:	93 reference(s)