Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Itga5tm1Hyn
Name:	integrin alpha 5 (fibronectin receptor alpha); targeted mutation 1, Richard Hynes
MGI ID:	MGI:1857207
Synonyms:	alpha5-, alpha5-null
Gene:	Itga5  Location: Chr15:103252713-103275190 bp, - strand  Genetic Position: Chr15, 58.9 cM
Alliance:	Itga5tm1Hyn page

Germline Transmission:	Earliest citation of germline transmission: J:16248
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin resistance cassette replaced 330 bp of the gene, deleting most of the first exon. (J:16248)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Itga5tm1Hyn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga5 Mutation:	45 strains or lines available

Original:	J:16248 Yang JT, et al., Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development. 1993 Dec;119(4):1093-105
All:	22 reference(s)