Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Irf1tm1Mak
Name:	interferon regulatory factor 1; targeted mutation 1, Tak Mak
MGI ID:	MGI:1857205
Synonyms:	IRF-1-
Gene:	Irf1  Location: Chr11:53660841-53669200 bp, + strand  Genetic Position: Chr11, 32.0 cM
Alliance:	Irf1tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:64286
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 1.2 kb region of the gene, which encodes for amino acids 63 - 223, deleting part of the DNA-binding domain of the protein. (J:64286)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Irf1tm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf1 Mutation:	19 strains or lines available

Original:	J:64286 Matsuyama T, et al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993 Oct 8;75(1):83-97
All:	137 reference(s)