About   Help   FAQ
Il2tm1Hor
Targeted Allele Detail
Summary
Symbol: Il2tm1Hor
Name: interleukin 2; targeted mutation 1, Ivan Horak
MGI ID: MGI:1857191
Synonyms: Il2-, IL-2-, IL-2 KO, IL-2null
Gene: Il2  Location: Chr3:37174862-37180103 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Alliance: Il2tm1Hor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39989
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin-resistance gene into the third exon introduced several stop codons in all reading frames. (J:39989)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 22 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Il2tm1Hor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:  41 strains or lines available
References
Original:  J:39989 Schorle H, et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 1991 Aug 15;352(6336):621-4
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory