Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cgatm1Sac
Name:	glycoprotein hormones, alpha subunit; targeted mutation 1, Sally A Camper
MGI ID:	MGI:1857152
Synonyms:	TSHalpha -
Gene:	Cga  Location: Chr4:34893779-34907370 bp, + strand  Genetic Position: Chr4, 16.86 cM
Alliance:	Cgatm1Sac page

Germline Transmission:	Earliest citation of germline transmission: J:28450
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted into the third exon. In situ hybridization and RT-PCR experiments confirmed that the transcript was not present in pituitary of homozygous mice (data not shown). (J:28450)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cga Mutation:	15 strains or lines available

Original:	J:28450 Kendall SK, et al., Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. Genes Dev. 1995 Aug 15;9(16):2007-19
All:	8 reference(s)