Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Btktm1Wk
Name:	Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1, Wasif Kahn
MGI ID:	MGI:1857138
Synonyms:	Btk-, Btk-kin-/GL, BtkM
Gene:	Btk  Location: ChrX:133443085-133484319 bp, - strand  Genetic Position: ChrX, 56.18 cM
Alliance:	Btktm1Wk page

Germline Transmission:	Earliest citation of germline transmission: J:28968
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 13 and 14 was replaced with a neomycin resistance cassette. These sequences encode the beginning of the kinase domain. (J:28968)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Btk Mutation:	22 strains or lines available

Original:	J:28968 Khan WN, et al., Defective B cell development and function in Btk-deficient mice. Immunity. 1995 Sep;3(3):283-99
All:	82 reference(s)