Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Agtr2tm1Gsb
Name:	angiotensin II receptor, type 2; targeted mutation 1, Gregory S Barsh
MGI ID:	MGI:1857123
Synonyms:	AT2-KO
Gene:	Agtr2  Location: ChrX:21350863-21355072 bp, + strand  Genetic Position: ChrX, 16.71 cM
Alliance:	Agtr2tm1Gsb page

Germline Transmission:	Earliest citation of germline transmission: J:29456
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette was inserted into exon 3, into sequences encoding the region after the first putative transmembrane domain of the receptor. A 209 bp segment of the coding region is also deleted. Northern blot analysis demonstrated that no transcript is produced from this allele in homozygous female or hemizygous male mice. (J:29456)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr2 Mutation:	11 strains or lines available

Original:	J:29456 Hein L, et al., Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 1995 Oct 26;377(6551):744-7
All:	36 reference(s)