Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Rab23opb Name: RAB23, member RAS oncogene family; open brain MGI ID: MGI:1856980 Synonyms: opb1 Gene: Rab23  Location: Chr1:33758968-33781645 bp, + strand  Genetic Position: Chr1, 12.8 cM Alliance: Rab23opb page

Rab23opb/Rab23opb embryos display neural tube closure defects, missing eyes, preaxial duplications of limbs, and detached skin Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

NMRI

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: An A-to-T mutation at coding nucleotide 115 of the encoded mRNA (c.115A>T) that altered codon 39 from a lysine to a stop codon (p.K39*). If the peptide is translated, it will lack the domains required for guanine nucleotide and Rab effector binding. (J:70423) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rab23 Mutation:	33 strains or lines available

Original:	J:21617 Gunther T, et al., Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994 Nov;120(11):3119-30
All:	7 reference(s)