Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grem1ld-J
Name:	gremlin 1, DAN family BMP antagonist; limb deformity Jackson
MGI ID:	MGI:1856290
Synonyms:	Fmnld-J, footless, ldJ
Gene:	Grem1  Location: Chr2:113579020-113588993 bp, - strand  Genetic Position: Chr2, 57.43 cM
Alliance:	Grem1ld-J page

Strain of Origin:

CBA/Ca-Bmp5se

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A G-to-A transition mutation at the boundary between intron 1 and exon 2 disrupts pre-mRNA splicing by eliminating the AG motif at the 3' splice acceptor site. The aberrant transcript expressed by this allele has a 65 base deletion of the 5' part of exon 2 and is missing the translational start codon. (J:43337, J:91385) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grem1 Mutation:	16 strains or lines available

Original:	J:171 Green MC, Limb deformity, ld. Mouse News Lett. 1962;26:34-5
All:	13 reference(s)