Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Ednrbs Name: endothelin receptor type B; piebald MGI ID: MGI:1856148 Synonyms: pied spotting, s Gene: Ednrb  Location: Chr14:104052055-104081764 bp, - strand  Genetic Position: Chr14, 53.05 cM Alliance: Ednrbs page

Ednrbs/Ednrbs Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

old mutant of the mouse fancy

Allele Type:    Spontaneous Mutation:    Transposon insertion   Mutation details: This mutation is allelic to a targeted mutation for this gene. Homozygous mice produce approximately 25% of the normal levels of transcript from this allele. RT-PCR analysis demonstrated that no alterations in the coding sequence would result in any alteration of the amino acid sequence. A 5.5 kb retrotransposon-like element is found in intron 1. About 75% of the mRNA produced is an aberrant 6.5 kb form lacking exons 2-6 but containing exon 1. The remaining 25% of the mRNA formed is of normal, 4.4 kb, size. (J:22206, J:56133, J:110573) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

List all tumor models in MMHCdb carrying Ednrbs

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 19 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:	107 strains or lines available

Original:	J:23183 Dunn LC, Types of white spotting in mice. Am Naturalist. 1920 Nov-Dec;54:465-95
All:	41 reference(s)