Smok1 MGI Mouse Gene Detail - MGI:1351488 - sperm motility kinase 1

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Smok1 Gene Detail

Symbol

Smok1
Name

sperm motility kinase 1
Synonyms

Smok, Tcr1, Tcr-1

Feature Type

protein coding gene
IDs

MGI:1351488
NCBI Gene: 27262
Alliance

gene page
Candidate for QTL

1 QTL

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Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 17, Syntenic
Mapping Data

5 experiments

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

1
Transgenic

1
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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All Sequences

2
UniProt

1

NCBI Gene

27262

Representative Sequences				Length	Strain/Species	Flank
	genomic	AJ245455	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	1590	STOCK t	± kb
	polypeptide	Q9QYZ4	UniProt \| EBI \| MGI Sequence Detail	484	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015970 sperm motility kinase 1

(term hierarchy)

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All nucleic 2

Genomic 2

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MGD-MRK-14843, MGD-MRK-14844, MGI:98552

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Summaries

All 26

Gene Ontology 5

Phenotypes 2
Earliest

J:6915 Klein J, et al., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17. Immunogenetics. 1982;16(4):285-317
Latest

J:183481 Bauer H, et al., The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genet. 2012 Mar;8(3):e1002567

Smok1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Nidd2n	Chr14, 31.49 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 14, Smok1 (7.7 cM, formerly Tcr1) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Nidd2n (22.5 cM) maps near candidate gene Smok1.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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