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Gene Expression Data
Assay Details
Assay
Reference: J:57676 McGrath KE, et al., Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999 Sep 15;213(2):442-56
Assay type: RNA in situ
MGI Accession ID: MGI:1346815
Gene symbol: Cxcr4
Gene name: C-X-C motif chemokine receptor 4
Probe: CXCR4 cDNA
Probe preparation: Antisense labelled with P33 RNA
Visualized with: Autoradiography
Results
Specimen 2B,D: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present 2B
TS11: yolk sac mesoderm Present 2B
TS11: parietal endoderm Present Regionally restricted 2B , 2D
TS11: chorion ectoderm Absent 2B
TS11: embryo ectoderm Absent 2B

Specimen 3A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum Present Regionally restricted 3A Expression is in the anterior region.
TS13: neural tube Present Regionally restricted 3A Expression is in the anterior region.
TS13: hindgut diverticulum endoderm Present 3A
TS13: somatopleure Present 3A
TS13: splanchnopleure Present 3A
TS13: trunk unsegmented mesenchyme Present 3A
TS13: embryo ectoderm Present Regionally restricted 3A Expression is in ectoderm overlying the somatopleure.

Specimen 4A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: aortico-pulmonary spiral septum Present 4A
TS17: stomach Present 4A
TS17: Rathke's pouch Present Regionally restricted 4A Expression is at the caudal side of the involution.
TS17: foregut Present Regionally restricted 4A Expression is in a subset of foregut derivatives.
TS17: hindbrain Present Regionally restricted 4A Expression is in the rhombic lip of the roof.
TS17: diencephalon floor plate Present Regionally restricted 4A Expression is in the outpocketing of the floor as it expands to fuse with the roof.
TS17: brain Present Regionally restricted 4A Expression is in the developing hypothalamus.
TS17: arterial system Present Regionally restricted 4A Expression is striped in the aorta and along the intersegmental arteries.
TS17: dorsal aorta Present Regionally restricted 4A Expression is striped in the aorta and along the intersegmental arteries.
TS17: liver Absent 4A
TS17: extraembryonic component Absent 4A Expression was not detected in the yolk sac.
TS17: frontal process ectoderm Present 4A

Specimen 5A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 5A Expression is in the ventral mantle layer.
TS17: dorsal root ganglion Present 5A

Specimen 5C,E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: metencephalon Present Regionally restricted 5E , 5C Expression is in the pons and ventral rhombic lip.
TS19: myelencephalon Present 5E Expression in medulla oblongata.
TS19: midbrain Present Regionally restricted 5E Expression is in the midbrain aspect of the midbrain/hindbrain border.
TS19: 4th ventricle Present Regionally restricted 5C Expression is along the wall with a gap in a region that expresses Sdf1.
TS19: cardiovascular system Present Regionally restricted 5C Expression is in various vascular endothelia including the pia matter.
TS19: Rathke's pouch Present 5E

Specimen 6E,F: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: thyroid gland Present 6E

Specimen 4C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: 4th ventricle Present 4C
TS20: diencephalon floor plate Present 4C
TS20: spinal cord Strong Regionally restricted 4C Expression is in the ventral mantle layer.
TS20: nervous system Weak Regionally restricted 4C Expression is in the alar plates.
TS20: dorsal root ganglion Strong 4C
TS20: hypothalamus Present 4C
TS20: thalamus Present 4C

Specimen 6A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: sympathetic nervous system Present Regionally restricted 6A Expression is in the dorsal and thoracic sympathetic ganglia.
TS20: spinal nerve Present 6A
TS20: cystic duct Present 6A
TS20: left lung epithelium Present 6A
TS20: right lung epithelium Present 6A
TS20: skin Present 6A
TS20: extraembryonic vascular system Present Regionally restricted 6A Expressed in vitelline/umbilical vessel epithelium.
TS20: cardiovascular system Present Regionally restricted 6A Expression is in some embryonic vessels.
TS20: frontal process mesenchyme Present 6A

Specimen 6C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: heart ventricle Present Regionally restricted 6C Expression is in the ventricle wall cappillary.
TS20: outflow tract Present Regionally restricted 6C Expression is at the base of the outflow tract.
TS20: right atrium valve Present 6C

Specimen 6G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: trunk Present Regionally restricted 6G Expression is in the distal facial ectoderm.
TS22: lower jaw epithelium Present 6G
TS22: oral region Present Regionally restricted 6G Expression is along the caudal edge of the dental almina of tooth primordia.

Specimen 4E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: 4th ventricle Present Regionally restricted 4E Expression is in the neural epithelium lining.
TS22: hypothalamus Present 4E
TS22: olfactory lobe Present 4E
TS22: thalamus Present 4E
TS22: aortico-pulmonary spiral septum Present 4E
TS22: skin Present Regionally restricted 4E Expression is in the facial skin.
TS22: lateral ventricle Present Regionally restricted 4E Expression is in the vascular pia matter.
TS22: stomach Present Regionally restricted 4E
TS22: cardiovascular system Present Regionally restricted 4E Expression is in vascular beds including aortic and interstitial vessels.

Specimen 5G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: 4th ventricle Present Regionally restricted 5G Expression is tightly confined to the neuroepithelial lining.
TS22: hindbrain Present Regionally restricted 5G Expression is in the external granular layer of the ventral rhombic lip.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory