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Gene Expression Data
Assay Details
Assay
Reference: J:50462 Dassule HR, et al., Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol. 1998 Oct 15;202(2):215-27
Assay type: RNA in situ
MGI Accession ID: MGI:1340545
Gene symbol: Ptch1
Gene name: patched 1
Probe: M2-3
Probe preparation: RNA
Results
Specimen 1E: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component mesenchyme Strong Regionally restricted 1E Ptc is strongly expressed in the mesenchyme along the mesial-distal axis in a pattern that is complimentary to and somewhat broader than Shh.
TS18: tongue Present 1E
Specimen 1K: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandible primordium Strong Regionally restricted 1K Ptc is strongly expressed in the mesenchyme along the mesial-distal axis in a pattern that is complimentary to and somewhat broader than Shh.
TS19: tongue Present 1K
Specimen 1Q: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: mandible primordium Present Regionally restricted 1Q Ptc is expressed at high levels immediately beneath the thickened dental epithelium of the incisor. Ptc expression is completely down-regulated in the diastema.
TS20: tongue Present 1Q
Specimen 1W: embryonic day 12.0 (more )
Note: Tissue was embedded in 30% BSA, 0.49% gelatin, 20% sucrose in PBS and crosslinked with glutaraldehyde.
Structure Level Pattern Image Note
TS20: mandible primordium Present Regionally restricted 1W As earlier, Ptc is expressed at high levels immediately beneath the thickened involuted dental epithelium of the incisor. Unlike other stages, Ptc is also weakly expressed at the tip of the invaginating epithelial cells.
Specimen 1Z: embryonic day 12.5 (more )
Note: Tissue was embedded in 30% BSA, 0.49% gelatin, 20% sucrose in PBS and crosslinked with glutaraldehyde.
Structure Level Pattern Image Note
TS20: tongue Present Regionally restricted 1Z Ptc expression is restricted to the mesenchyme, located immediately beneath Shh-expressing cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
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