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Gene Expression Data
Assay Details
Assay
Reference: J:34586 Wehrle-Haller B, et al., Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos. Dev Biol. 1996 Aug 1;177(2):463-74
Assay type: RNA in situ
MGI Accession ID: MGI:1339471
Gene symbol: Dct
Gene name: dopachrome tautomerase
Probe: TRP-2 probe4
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 3A: embryonic day 11.5; Ph/Ph (more )
Note: Lateral view of hindlimb bud and tail.
Structure Level Pattern Image Note
TS19: tail mesenchyme derived from neural crest Present Single cells 3A Expression is in melanocyte precursors. In mutant embryos these cells do not reach the base of the hind limb bud.
TS19: trunk mesenchyme derived from neural crest Present Single cells 3A Expression is in melanocyte precursors. In mutant embryos these cells do not reach the base of the hind limb bud.

Specimen 3B: embryonic day 11.5; Ph/Ph (more )
Note: Lateral view of the mid-trunk region.
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Single cells 3B Expression is in melanocyte precursors. In mutant embryos, the cells are clustered in a segmental pattern dorsolaterally.

Specimen 3C: embryonic day 11.5 (more )
Note: Lateral view of the mid-trunk region.
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Single cells 3C Expression is in melanocyte precursors. The cells have a uniform distribution.

Specimen 3D: embryonic day 13.5 (more )
Note: Lateral view of the shoulder and ear.
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3D Expression is in melanocyte precursors.

Specimen 3E: embryonic day 13.5; Ph/Ph+ (more )
Note: Lateral view of the shoulder and ear.
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3E Expression is in melanocyte precursors. Mutant embryos have fewer cells.

Specimen 3F: embryonic day 13.5; Ph/Ph (more )
Note: Magnified view of the ear.
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3F Expression is in melanocyte precursors. In mutant embryos, there are very few cells.

Specimen 3G: embryonic day 13.5 (more )
Note: Hind limb bud and tail region
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3G Expression is in melanocyte precursors.

Specimen 3H: embryonic day 13.5; Ph/Ph+ (more )
Note: Hind limb bud and tail region
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3H Expression is in melanocyte precursors. Cells are present in the shoulder, absent in the mid-trunk region, reduced at the base of the hindlimb, and present in the tail.

Specimen 3I: embryonic day 13.5; Ph/Ph (more )
Note: Magnified view of the tail.
Structure Level Pattern Image Note
TS21: tail mesenchyme derived from neural crest Present Single cells 3I Expression is in melanocyte precursors. In mutant embryos, a few cells are present in dorsolateral locations.

Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest Present Single cells Expression is in melanocyte precursors.

Specimen not shown: embryonic day 12.5; Ph/Ph (more )
Structure Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest Present Single cells Expression is in a few cells at shoulder level but not in the trunk.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory