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Gene Expression Data
Assay Details
Assay
Reference: J:50259 Kil SH, et al., The alpha4 subunit of integrin is important for neural crest cell migration. Dev Biol. 1998 Oct 1;202(1):29-42
Assay type: Immunohistochemistry
MGI Accession ID: MGI:1335747
Gene symbol: Itga4
Gene name: integrin alpha 4
Antibody: PS-2
Detection system: Biotinylated secondary antibody/[Strept]avidin
Assay notes: Specimen was embedded in gelatin prior to cryosectioning.
Results
Specimen 4A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future prosencephalon neural crest Strong 4A

Specimen 4B: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future midbrain neural crest Strong 4B

Specimen 4C: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: anterior pro-rhombomere neural crest Strong 4C
TS13: 1st branchial arch Strong Regionally restricted 4C Migrating neural crest cells that have entered the first branchial arch demonstrated a strong integrin alpha-4 protein expression.
TS13: migrating neural crest Strong Regionally restricted 4C Migrating neural crest cells that have entered the first branchial arch demonstrated a strong integrin alpha-4 protein expression.

Specimen 4D: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trigeminal preganglion Strong 4D
TS15: dorsal root ganglion Present Regionally restricted 4D In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: migrating neural crest Present Regionally restricted 4D In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 4D In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.

Specimen 4E: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: dorsal root ganglion Present Regionally restricted 4E In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: migrating neural crest Present Regionally restricted 4E In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 4E In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: gut Present 4E

Specimen 4F: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: dorsal root ganglion Present Regionally restricted 4F In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: migrating neural crest Present Regionally restricted 4F In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 4F In the trunk region, neural crest cells displayed integrin alpha-4 immunoreactivity both during their migration as well as during condensation into dorsal root ganglia and other derivatives.
TS15: trunk somite Present Regionally restricted 4F Integrin alpha-4 immunoreactivity was noted in the myotome.

Specimen 4G: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: dorsal root ganglion Strong 4G
TS18: trunk somite Strong Regionally restricted 4G Expression in the myotome was pronounced.

Specimen 4H: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: forelimb bud apical ectodermal ridge Strong 4H
TS18: forelimb bud Strong Regionally restricted 4H Myoblasts of the forelimb showed prominent integrin alpha-4 immunoreactivity.

Specimen 4I: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: liver Strong 4I

Specimen not shown: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: heart Strong


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory