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Gene Expression Data
Assay Details
Assay
Reference: J:23774 Chen WH, et al., Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma. Development. 1995 Mar;121(3):681-91
Assay type: RNA in situ
MGI Accession ID: MGI:1335182
Gene symbol: Rarg
Gene name: retinoic acid receptor, gamma
Probe: Rarg cDNA4
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1B RAR[g] ct/ct: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 27 somites. This is a category 1/2 mutant.
Structure Level Pattern Image Note
TS16: caudal neuropore Strong 1B
TS16: tail Strong 1B
TS16: hindgut Weak 1B
TS16: neural tube Weak 1B

Specimen 1D RAR[g]: embryonic day 10.0 (more )
Note: This embryo has 27 somites.
Structure Level Pattern Image Note
TS16: hindgut Weak 1D
TS16: neural tube Weak 1D
TS16: caudal neuropore Strong 1D
TS16: tail Strong 1D

Specimen 3B: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 1/2 mutant. The level of this section is shown in Fig. 3A. This mutant embryo does not show a phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 3B Expression in this unaffected mutant is similar to wild-type embryos.
TS16: hindgut mesenchyme Present 3B Expression in this unaffected mutant is similar to wild-type embryos.

Specimen 3C: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 1/2 mutant. The level of this section is shown in Fig. 3A. This mutant embryo does not show a phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 3C Expression in this unaffected mutant is similar to wild-type embryos.
TS16: hindgut mesenchyme Present 3C Expression in this unaffected mutant is similar to wild-type embryos.

Specimen 3D: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 1/2 mutant. The level of this section is shown in Fig. 3A. This mutant embryo does not show a phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 3D Expression in this unaffected mutant is similar to wild-type embryos.
TS16: hindgut mesenchyme Present 3D Expression in this unaffected mutant is similar to wild-type embryos.

Specimen 3E: embryonic day 10.0 (more )
Note: This embryos has 26 somites.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 3E
TS16: hindgut mesenchyme Present 3E

Specimen 3F: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 4/5 mutant. The level of this section is shown in Fig. 3A. This mutant shows a severe phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Weak 3F This embryo shows a decreased expression compared to wild type.
TS16: hindgut mesenchyme Weak 3F This embryo shows a decreased expression compared to wild type.

Specimen 3G: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 4/5 mutant. The level of this section is shown in Fig. 3A. This mutant shows a severe phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Weak 3G This embryo shows a decreased expression compared to wild type.
TS16: hindgut mesenchyme Weak 3G This embryo shows a decreased expression compared to wild type.

Specimen 3H: embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 28 somites. This is a category 4/5 mutant. The level of this section is shown in Fig. 3A. This mutant shows a severe phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Weak 3H This embryo shows a decreased expression compared to wild type.
TS16: hindgut mesenchyme Weak 3H This embryo shows a decreased expression compared to wild type.

Specimen 4A': embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: caudal neuropore Strong 4A'
TS16: hindgut mesenchyme Strong 4A'

Specimen 4B': embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This is a category 1/2 mutant. This mutant embryo displays a mild phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 4B'
TS16: hindgut mesenchyme Present 4B'

Specimen 4C': embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This is a category 3 mutant. This mutant embryo displays a moderate phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 4C'
TS16: hindgut mesenchyme Present 4C'

Specimen 4D': embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This is a category 4/5 mutant.This mutant embrryo displays a severe phenotype.
Structure Level Pattern Image Note
TS16: caudal neuropore Present 4D'
TS16: hindgut mesenchyme Present 4D'

Specimen 6A': embryonic day 10.0; Grhl3ct/Grhl3ct (more )
Note: This embryo has 31 somites. This embryo is a vehicle-treated control.
Structure Level Pattern Image Note
TS16: tail Weak 6A'


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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory