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Gene Expression Data
Assay Details
Assay
Reference: J:43310 Herault Y, et al., Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development. 1997 Sep;124(18):3493-500
Assay type: RNA in situ
MGI Accession ID: MGI:1333526
Gene symbol: Hoxd13
Gene name: homeobox D13
Probe: probe A
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4A left: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted 4A wild type
TS19: hindlimb bud Present Regionally restricted 4A wild type
TS19: reproductive system Present Regionally restricted 4A wild type
Specimen 4A right: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/+, LnpkUl/Lnpk+ (more )
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted 4A Ul/HoxDDel Distribution of transcripts is different than in wild-type embryos.
TS19: hindlimb bud Present Regionally restricted 4A Ul/HoxDDel Distribution of transcripts is different than in wild-type embryos.
TS19: reproductive system Present Regionally restricted 4A Ul/HoxDDel Distribution of transcripts is different than in wild-type embryos.
Specimen 4B left: embryonic day 11.5 (more )
Note: This embryo is a close up of the embryo shown on the left of Figure 4A.
Structure Level Pattern Image Note
TS19: reproductive system Present Regionally restricted 4B wild type Expression is in the distal portion of the genital eminence.
Specimen 4B right: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/+, LnpkUl/Lnpk+ (more )
Note: This embryo is a close up of the embryo shown on the right of Figure 4A.
Structure Level Pattern Image Note
TS19: reproductive system Weak Regionally restricted 4B Ul/HoxDDel Expression is much weaker than it is in wild-type embryos.
Specimen 4C left: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate Present Regionally restricted 4C wild type Expression is in the digits, and not in zeugopods.
TS19: future arm Absent 4C wild type Expression is in the digits, and not in zeugopods.
Specimen 4C middle: embryonic day 11.5; LnpkUl/Lnpk+ (more )
Structure Level Pattern Image Note
TS19: future arm Present Regionally restricted 4C Ul/+ Expression is in the digits. There is ectopic expression in the zeugopod from the Ul allele.
TS19: handplate Present Regionally restricted 4C Ul/+ Expression is in the digits. There is ectopic expression in the zeugopod from the Ul allele.
Specimen 4C right: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/+, LnpkUl/Lnpk+ (more )
Structure Level Pattern Image Note
TS19: future arm Present Regionally restricted 4C Ul/HoxDDel In these mutants a decrease in expression is observed in digits II and V, while ectopic expression is seen in the zeugopod.
TS19: handplate Present Regionally restricted 4C Ul/HoxDDel In these mutants a decrease in expression is observed in digits II and V, while ectopic expression is seen in the zeugopod.
Specimen 4D left: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate Present Regionally restricted 4D wild type Expression is in the digits, and not in zeugopods.
TS19: future leg Absent 4D wild type Expression is in the digits, and not in zeugopods.
Specimen 4D middle: embryonic day 11.5; LnpkUl/Lnpk+ (more )
Structure Level Pattern Image Note
TS19: footplate Present Regionally restricted 4D Ul/+ Expression is in the digits. There is ectopic expression in the zeugopod from the Ul allele.
TS19: future leg Present Regionally restricted 4D Ul/+ Expression is in the digits. There is ectopic expression in the zeugopod from the Ul allele.
Specimen 4D right: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/+, LnpkUl/Lnpk+ (more )
Structure Level Pattern Image Note
TS19: footplate Present Regionally restricted 4D Ul/HoxDDel In these mutants a decrease in expression is observed in the digits, while ectopic expression is seen in the zeugopod.
TS19: future leg Present Regionally restricted 4D Ul/HoxDDel In these mutants a decrease in expression is observed in the digits, while ectopic expression is seen in the zeugopod.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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