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Gene Expression Data
Assay Details
Assay
Reference: J:52597 Tanaka M, et al., The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999 Mar;126(6):1269-80
Assay type: Immunohistochemistry
MGI Accession ID: MGI:1330203
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody coupled to alkaline phosphatase
Results
Specimen 2J +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 2J +/+
TS15: branchial arch artery Present 2J +/+
TS15: dorsal aorta Present 2J +/+
TS15: intersomitic artery Present 2J +/+

Specimen 2J -/-: embryonic day 9.5; Nkx2-5tm1Siz/Nkx2-5tm1Siz (more )
Structure Level Pattern Image Note
TS15: branchial arch artery Present 2J -/- Blood vessels, such as these, are poorly developed in the mutant.
TS15: dorsal aorta Present 2J -/- Blood vessels, such as these, are poorly developed in the mutant.
TS15: intersomitic artery Present 2J -/- Blood vessels, such as these, are poorly developed in the mutant.

Specimen 3B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3B Expressed in blood vessels.

Specimen 3C: embryonic day 9.5; Nkx2-5tm1Siz/Nkx2-5tm1Siz (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3C No defined vasculatures could be observed in the mutant, only enlarged channels, which contained few blood cells.

Specimen 3D: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3D Expression is seen in large vitelline vasculatures.

Specimen 3E: embryonic day 9.5; Nkx2-5tm1Siz/Nkx2-5tm1Siz (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3E No defined vasculatures could be observed in the mutant, only enlarged channels, which contained few blood cells.

Specimen 3F: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3F Expression is observed in a fine network of small vessels.

Specimen 3G: embryonic day 9.5; Nkx2-5tm1Siz/Nkx2-5tm1Siz (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present 3G No defined vasculatures could be observed in the mutant, only enlarged channels, which contained few blood cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory