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Gene Expression Data
Assay Details
Assay
Reference: J:49252 Hardcastle Z, et al., The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development. 1998 Aug;125(15):2803-11
Assay type: RNA in situ
MGI Accession ID: MGI:1320904
Gene symbol: Gli3
Gene name: GLI-Kruppel family member GLI3
Probe: Gli3 probe2
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1F: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Present 1F Expression of Gli3 was widespread.
TS19: maxillary process Present 1F Expression of Gli3 was widespread.

Specimen 1L: embryonic day 12.5 (more )
Note: Early tooth bud stage.
Structure Level Pattern Image Note
TS20: mandibular process Present Regionally restricted 1L Gli3 was significantly more localized in the mesenchyme around the tooth germs than at previous stages of development.
TS20: maxillary process Present Regionally restricted 1L Gli3 was significantly more localized in the mesenchyme around the tooth germs than at previous stages of development.

Specimen 1R: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor Strong Regionally restricted 1R In the molars and mandibular incisors, Gli3 was expressed uniformly in the mesenchyme surrounding the dental organ.
TS21: lower jaw molar Strong Regionally restricted 1R In the molars and mandibular incisors, Gli3 was expressed uniformly in the mesenchyme surrounding the dental organ.
TS21: upper jaw molar Strong Regionally restricted 1R In the molars and mandibular incisors, Gli3 was expressed uniformly in the mesenchyme surrounding the dental organ.
TS21: upper jaw incisor Strong Regionally restricted 1R In the maxillary incisors, the mesenchymal expression was greater on the buccal side of the tooth germ.

Specimen 1X: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: lower jaw mesenchyme Present Regionally restricted 1X Expression is in the mesenchyme surrounding the dental organ.
TS22: upper jaw mesenchyme Present Regionally restricted 1X Expression is in the mesenchyme surrounding the dental organ.
TS22: molar mesenchyme Weak 1X
TS22: enamel organ Absent 1X , 1D'


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory