Inbred Strains
of Rats: ZDF
Inbr. F10.
Origin: "Zucker" fatty rats of undefined outbred background, inbred with
selection for non-insulin-dependent diabetes mellitus by mating diabetic
homozygous fatty males to heterozygous sisters (Peterson et al 1990b).
Characteristics
Develops overt diabetes associated with decreased plasma insulin levels.
Depending on age can be sub-divided into obese, mildly diabetic (blood
glucose <11 mM) and obese severely diabetic (blood glucose >20 mM) groups
(
Slieker et al, 1992). Develop quantifiable
retinal vascular changes (
Danis and Yang, 1993)
Danis R.
P. and Yang Y. H. (1993) Microvascular retinopathy in the Zucker diabetic
fatty rat. Investigative Ophthalmology & Visual Science 34,
2367-2371.
Peterson
R. G., Shaw W. N., Neel A.-A., Little L. A., and Eichberg J. (1990b) Zucker
diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus.
ILAR News 32, 16-19.
Slieker
L. J., Sundell K. L., Heath W. F., Osborne H. E., Bue J., Manetta J.,
and Sportsman J. R. (1992) Glucose transporter levels in tissues of spontaneously
diabetic Zucker fa fa rat (ZDF/Drt) and viable yellow mouse (Avy/a).
Diabetes 41, 187-193.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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