TMB

Inbr. F20+.

Colour: Agouti, with white on ventral surface.

Genet. A, hⁱ.

Origin: PL Broadhurst from stock selected by Tryon for good maze learning performance. Although TMB and TS1 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b).

---

Characteristics

High voluntary alcohol acceptance concentration (1/4) (Russell and Stern 1973). Low open field activity (8/8) (Rick and Fulker 1972). Show an unprecidented affinity for ethanol with stable intakes between 12.7 and 13.7 g/kg per day and preference ratios exceeding 0.75 for ethanol concentrations ranging between 15 and 29% (Amit and Smith, 1992)

---

Amit Z. and Smith B. R. (1992) Differential ethanol intake in Tryon Maze-Bright and Tryon Maze-Dull rats - implications for the validity of the animal-model of selectively bred rats for high ethanol-consumption. Psychopharmacology 108, 136-140.

Festing M. F. W. (1979b) Inbred strains in biomedical research, 1st ed. Macmillan Press, London, Basingstoke.

Rick J. T. and Fulker D. W. (1972) Some biochemical correlates of inherited behavourial differences. Prog. Brain Res. 36, 105-112.

Russell K. E. and Stern M. H. (1973) Sex and strain as factors in voluntary alcohol intake. Physiol. Behav. 10, 641-642.

---

INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK