SAMR1

Inbr. F?+49. Albino, c. Origin: Dr. Toshio Takeda, Dept. of Senescence Biology, Chest Disease Research Institute, Kyoto University, Sakyo-ku, Kyoto 606, Japan, from AKR/J mice imported from J in 1968 and crossed (?) with mice of an unknown strain, followed by sib mating since 1975 with selection for normal life-span.

Characteristics:

About 25% and 22% of the mice aged over 16 months which die naturally have lymphocytic and histiocytic neoplasia, respectively. About 68% of females which die after 20 months of age have ovarian cysts. Median survival is 568 days in conventional conditions. Good passive avoidance skills up to 22 months of age. Used as a normally-aging control strain for the SAMP (Senescence-Accelerated Mouse) strains (see Takeda et al 1981, Hosokawa et al 1984, Takeda et al 1991)

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Hosokawa M., Kasai R., Higuchi K., Takeshita S., Shimizu K., Hamamoto H., Honma A., Irino M., Toda K., Matsumura A., Matsushita T., and Takeda T. (1984) Grading score system: A method for evaluation of the degree of senescence in senescence accelerated mouse (SAM). Mech. Ageing Dev. 26, 91-102.

Takeda T., Hosokawa M., Takeshita S., Irino M., Higuchi K., Matsushita T., Tomita Y., Yasuhira K., Hamamoto H., Shimizu K., Ishii M., and Yamamuro T. (1981) A new murine model of accelerated senescence. Mech. Ageing Dev. 17, 183-194.

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK