Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4	hm5	hm6	ht7	cx8	cx9	cx10	cx11	cx12	cx13
show or hide all annotated terms Sex:
behavior/neurological					N
behavior/neurological phenotype					N
cellular					√
increased renal tubule apoptosis					√
craniofacial					√
abnormal periodontal ligament morphology					√
periodontal ligament hypercellularity					√
digestive/alimentary system						√
salivary gland epithelial hyperplasia						√
abnormal stomach mucosa morphology						√
endocrine/exocrine glands						√						√	√
salivary gland epithelial hyperplasia						√
enlarged thymus													√
thymus hyperplasia													√
increased T cell derived lymphoma incidence												√	√
growth/size/body					√			√
abnormal periodontal ligament morphology					√
periodontal ligament hypercellularity					√
decreased body weight								√
hematopoietic system					N							√	√
hematopoietic system phenotype					N
enlarged thymus													√
thymus hyperplasia													√
increased T cell derived lymphoma incidence												√	√
homeostasis/metabolism					N
homeostasis/metabolism phenotype					N
immune system	√	√			√		√					√	√
immune system phenotype					N
enlarged thymus													√
thymus hyperplasia													√
increased T cell derived lymphoma incidence												√	√
abnormal humoral immune response	√
tubular nephritis					√
decreased susceptibility to bacterial infection		√					√
integument			√		√				√
thin hypodermis									√
abnormal cutaneous collagen fibril morphology			√		√				√
thin dermal layer			√		√				√
loose skin					√
thin skin					√
decreased skin tensile strength			√		√				√
mortality/aging								√				√	√
premature death												√
decreased tumor-free survival time													√
perinatal lethality								√
muscle			√		√
abnormal tendon morphology			√		√
neoplasm						N						√	√
neoplasm						N
increased tumor incidence												√	√
increased T cell derived lymphoma incidence												√	√
increased hemangiosarcoma incidence													√
renal/urinary system					√
increased renal tubule apoptosis					√
tubular nephritis					√
increased glomerular capsule space					√
abnormal renal tubule epithelium morphology					√
renal interstitial fibrosis					√
hydronephrosis					√
kidney atrophy					√
renal tubule atrophy					√
dilated renal tubule					√
reproductive system				√				√	√	√	√
short gestation period								√
delayed parturition											√
early parturition								√		√
reduced female fertility				√				√
decreased litter size								√
male infertility									√
respiratory system												√	√
respiratory distress												√	√
skeleton			√		√				√
skeleton phenotype					N
abnormal periodontal ligament morphology					√
periodontal ligament hypercellularity					√
abnormal tendon morphology			√		√
decreased length of long bones									√
increased diameter of long bones									√
abnormal bone structure			√
abnormal bone collagen fibril morphology									√
decreased bone mineral density									√
decreased compact bone mass									√
decreased trabecular bone mass									√
vision/eye					N
vision/eye phenotype					N