Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4		hm5	cn6	cn7	cx8	cx9	cx10	cx11	cx12	cx13	cx14	cx15	cx16	cx17	cx18	cx19	cx20	cx21	cx22	cx23	cx24	cx25	cx26	cx27
show or hide all annotated terms Sex:
adipose tissue																						N
adipose tissue phenotype																						N
behavior/neurological	√			√	√	√																				√
abnormal learning/memory/conditioning				√	√
abnormal inhibitory learning				√	√
abnormal object recognition memory				√	√
abnormal long-term object recognition memory				√	√
impaired long-term object recognition memory				√	√
abnormal spatial learning				√	√
abnormal emotion/affect behavior	√			√	√
behavioral despair	√			√	√
increased anxiety-related response	√			√	√
increased fear-related response	√
tremors																										√
increased locomotor activity	√
abnormal sleep pattern	√
abnormal frequency of paradoxical sleep	√
seizures						√
cardiovascular system				√	√																					√
abnormal capillary morphology				√	√
abnormal heart morphology				√	√
abnormal heart development				√	√
decreased heart weight				√	√
abnormal heart ventricle morphology				√	√
abnormal interventricular septum morphology				√	√
decreased heart left ventricle wall thickness				√	√
decreased heart left ventricle anterior wall thickness				√	√
decreased heart left ventricle posterior wall thickness				√	√
dilated heart left ventricle				√	√
abnormal cardiovascular system physiology				√	√
decreased cardiac muscle contractility				√	√
abnormal blood-brain barrier function																										√
cellular			√	√	√							√			√		√									√
teratozoospermia												√
abnormal glial cell morphology			√												√
abnormal CNS glial cell morphology				√	√
abnormal astrocyte morphology				√	√
abnormal microglial cell morphology				√	√
gliosis																										√
abnormal myoblast migration				√	√
increased sperm motility												√
increased sperm progressive motility												√
abnormal skeletal muscle satellite cell proliferation				√	√
abnormal glial cell physiology																	√
digestive/alimentary system				√	√					√	√																	√
digestive/alimentary phenotype										N	N
increased susceptibility to induced colitis				√	√																							√
esophageal inflammation										√	√
endocrine/exocrine glands	√			√
abnormal pancreatic alpha cell mass	√
abnormal involution of the mammary gland				√
decreased glucagon secretion	√
decreased insulin secretion	√
growth/size/body				√	√
decreased body weight				√	√
obese				√	√
hematopoietic system	√		√	√	√								√						√		√				N
hematopoietic system phenotype																									N
abnormal microglial cell morphology				√	√
abnormal lymphopoiesis													√
decreased pro-B cell number	√												√
abnormal T cell differentiation				√	√
abnormal CD4-positive T cell differentiation																					√
abnormal myelopoiesis													√
increased regulatory T cell number																					√
decreased T cell number				√	√
abnormal hematopoietic stem cell morphology													√
abnormal effector T cell morphology																			√
abnormal T cell physiology			√
decreased cytotoxic T cell cytolysis				√	√
homeostasis/metabolism	√		√	√	√			N							√			N		N	√			√		√
homeostasis/metabolism phenotype								N										N		N
abnormal homeostasis				√	√
decreased circulating interleukin-6 level																					√
increased body temperature	√
abnormal oxygen consumption				√	√
abnormal glucose homeostasis	√
decreased glucagon secretion	√
decreased insulin secretion	√
increased circulating glucose level				√	√
impaired glucose tolerance	√
abnormal acute phase protein level				√	√
abnormal tumor necrosis factor level																										√
abnormal exercise endurance				√	√
decreased incidence of tumors by chemical induction				√	√
abnormal wound healing																								√
abnormal bone healing				√	√
delayed wound healing			√
impaired wound healing			√
decreased susceptibility to injury			√												√
immune system	√		√	√	√		N	√	√	√	√		√	√		N			√		√					√	N	√
immune system phenotype							N	N						N		N											N
abnormal microglial cell morphology				√	√
abnormal lymphopoiesis													√
decreased pro-B cell number	√												√
abnormal T cell differentiation				√	√
abnormal CD4-positive T cell differentiation																					√
abnormal myelopoiesis													√
increased regulatory T cell number																					√
decreased T cell number				√	√
abnormal effector T cell morphology																			√
abnormal T cell physiology			√
decreased cytotoxic T cell cytolysis				√	√
decreased circulating interleukin-6 level																					√
abnormal acute phase protein level				√	√
abnormal tumor necrosis factor level																										√
decreased interferon-gamma secretion	√
decreased interleukin-17 secretion			√																		√
increased interleukin-4 secretion	√
abnormal interleukin-6 secretion	√
decreased susceptibility to experimental autoimmune encephalomyelitis																					√
abnormal inflammatory response			√						√
increased susceptibility to induced colitis				√	√																							√
esophageal inflammation										√	√
decreased susceptibility to induced arthritis	√
increased susceptibility to induced arthritis									√
decreased susceptibility to endotoxin shock														√
skin inflammation								√
increased susceptibility to bacterial infection				√	√
increased susceptibility to bacterial infection induced morbidity/mortality			√
increased susceptibility to Poxviridae infection				√	√
integument				√				√
integument phenotype								N
abnormal involution of the mammary gland				√
skin inflammation								√
hyperkeratosis								√
thick skin								√
liver/biliary system			√	√	√															√
hepatic necrosis				√	√
increased hepatocellular carcinoma incidence																				√
liver degeneration				√	√
abnormal oval cell physiology			√
mortality/aging			√					N															√
mortality/aging								N
increased susceptibility to bacterial infection induced morbidity/mortality			√
preweaning lethality, complete penetrance																							√
muscle				√	√																	N
muscle phenotype																						N
decreased cardiac muscle contractility				√	√
abnormal myoblast migration				√	√
abnormal skeletal muscle satellite cell proliferation				√	√
abnormal skeletal muscle fiber morphology				√	√
neoplasm		√		√	√															√		√
abnormal tumor incidence																						√
decreased incidence of tumors by chemical induction				√	√
increased hepatocellular carcinoma incidence																				√
increased tumor incidence following infection		√
nervous system			√	√	√	√									√		√									√
abnormal glial cell morphology			√												√
abnormal CNS glial cell morphology				√	√
abnormal astrocyte morphology				√	√
abnormal microglial cell morphology				√	√
gliosis																										√
abnormal cerebellum white matter morphology																										√
abnormal neuron morphology				√	√
abnormal brain interneuron morphology				√	√
abnormal axon morphology				√	√
abnormal nervous system physiology				√	√
seizures						√
abnormal blood-brain barrier function																										√
abnormal glial cell physiology																	√
abnormal neuron physiology				√	√
renal/urinary system								N
renal/urinary system phenotype								N
reproductive system												√								N
reproductive system phenotype																				N
teratozoospermia												√
increased sperm motility												√
increased sperm progressive motility												√
enhanced male fertility												√
abnormal epididymis physiology												√
respiratory system				√	√
abnormal pulmonary gas exchange				√	√
skeleton	√			√	√				√
abnormal bone healing				√	√
decreased susceptibility to induced arthritis	√
increased susceptibility to induced arthritis									√
decreased bone mineral density				√	√
vision/eye				√	√
retina outer nuclear layer degeneration				√	√