| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | autosomal dominant hypophosphatemic rickets | FGF23* | Fgf23* | 2 models | Alliance of Genome Resources | ||
| autosomal dominant osteopetrosis 2 | CLCN7* | Clcn7* | 7 models | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 1 | TCIRG1* | Tcirg1* | 2 models | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 2 | TNFSF11* | Tnfsf11* | 3 models | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 3 | CA2* | Car2* | 1 model | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 4 | CLCN7* | Clcn7* | 2 models | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 5 | OSTM1* | Ostm1* | 1 model | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 6 | PLEKHM1* | Plekhm1* | 2 models | Alliance of Genome Resources | |||
| autosomal recessive osteopetrosis 8 | SNX10* | Snx10* | 2 models | Alliance of Genome Resources | |||
| cherubism 1 | SH3BP2* | Sh3bp2* | 2 models | Alliance of Genome Resources | |||
| craniotubular dysplasia Ikegawa type | TMEM53* | Tmem53* | 1 model | Alliance of Genome Resources | |||
| hereditary hypophosphatemic rickets with hypercalciuria | SLC34A1* | Slc34a1* | 2 models | Alliance of Genome Resources | |||
| hereditary multiple exostoses | EXT1* | Ext1* | 5 models | Alliance of Genome Resources | |||
| osteopathia striata with cranial sclerosis | AMER1* | Amer1* | 2 models | Alliance of Genome Resources | |||
| osteoporosis | TNFSF11* | Tnfsf11* | 1 model | Alliance of Genome Resources | |||
| Paget's disease of bone | SQSTM1* | Sqstm1* | 3 models | Alliance of Genome Resources | |||
| Paget's disease of bone | TNFRSF11A* | Tnfrsf11a* | 1 model | Alliance of Genome Resources | |||
| rickets | VDR* | Vdr* | 4 models | Alliance of Genome Resources | |||
| rickets | CYP27B1* | Cyp27b1* | 2 models | Alliance of Genome Resources | |||
| sclerosteosis 1 | SOST* | Sost* | 1 model | Alliance of Genome Resources | |||
| sclerosteosis 2 | LRP4* | Lrp4* | 2 models | Alliance of Genome Resources | |||
| X-linked hypophosphatemic rickets | PHEX* | Phex* | 20 models | Alliance of Genome Resources | |||
| | autosomal recessive hypophosphatemic rickets | DMP1 | Dmp1* | 1 model | Alliance of Genome Resources | ||
| autosomal recessive osteopetrosis 1 | CCDC154 | Ccdc154* | 1 model | Alliance of Genome Resources | |||
| bone remodeling disease | IDH2 | Idh2* | 1 model | Alliance of Genome Resources | |||
| Camurati-Engelmann disease | MITF | Mitf* | 1 model | Alliance of Genome Resources | |||
| craniometaphyseal dysplasia | ANKH | Ank* | 1 model | Alliance of Genome Resources | |||
| hereditary multiple exostoses | EXT2 | Ext2* | 1 model | Alliance of Genome Resources | |||
| idiopathic juvenile osteoporosis | MTNR1A | Mtnr1a* | 1 model | Alliance of Genome Resources | |||
| osteopetrosis | MITF | Mitf* | 1 model | Alliance of Genome Resources | |||
| osteopetrosis | CSF1 | Csf1* | 1 model | Alliance of Genome Resources | |||
| osteopetrosis | LRRK1 | Lrrk1* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | CIITA | Ciita* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | ID4 | Id4* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | IFNGR1 | Ifngr1* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | IRAK3 | Irak3* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | Ly6a* | 1 model | |||||
| osteoporosis | PLS3 | Pls3* | 2 models | Alliance of Genome Resources | |||
| osteoporosis | Terc* | 2 models | |||||
| osteoporosis | TNFRSF11B | Tnfrsf11b* | 1 model | Alliance of Genome Resources | |||
| osteoporosis | VDR | Vdr* | 1 model | Alliance of Genome Resources | |||
| Paget's disease of bone | INPP5D | Inpp5d* | 1 model | Alliance of Genome Resources | |||
| rickets | FAM20C | Fam20c* | 1 model | Alliance of Genome Resources | |||
| SOST-related sclerosing bone dysplasia | SOST | Sost* | 1 model | Alliance of Genome Resources | |||
| X-linked hypophosphatemic rickets | Gy* | 1 model | |||||
| | autosomal dominant craniodiaphyseal dysplasia | SOST* | Sost | Alliance of Genome Resources | |||
| autosomal dominant craniometaphyseal dysplasia | ANKH* | Ank | Alliance of Genome Resources | ||||
| autosomal dominant osteopetrosis 1 | LRP5* | Lrp5 | Alliance of Genome Resources | ||||
| autosomal recessive craniometaphyseal dysplasia | GJA1* | Gja1 | Alliance of Genome Resources | ||||
| autosomal recessive osteopetrosis 7 | TNFRSF11A* | Tnfrsf11a | Alliance of Genome Resources | ||||
| bent bone dysplasia syndrome 1 | FGFR2* | Fgfr2 | Alliance of Genome Resources | ||||
| bent bone dysplasia syndrome 2 | LAMA5* | Lama5 | Alliance of Genome Resources | ||||
| Camurati-Engelmann disease | TGFB1* | Tgfb1 | Alliance of Genome Resources | ||||
| familial expansile osteolysis | TNFRSF11A* | Tnfrsf11a | Alliance of Genome Resources | ||||
| hereditary hypophosphatemic rickets with hypercalciuria | SLC34A3* | Slc34a3 | 1 model | Alliance of Genome Resources | |||
| idiopathic juvenile osteoporosis | LRP5* | Lrp5 | Alliance of Genome Resources | ||||
| melorheostosis | MAP2K1* | Map2k1 | Alliance of Genome Resources | ||||
| osteopetrosis | PLEKHM1* | Plekhm1 | Alliance of Genome Resources | ||||
| osteopetrosis | SLC4A2* | Slc4a2 | Alliance of Genome Resources | ||||
| osteopetrosis | CA2* | Car2 | Alliance of Genome Resources | ||||
| osteoporosis | NRIP1* | Nrip1 | Alliance of Genome Resources | ||||
| osteoporosis | BGLAP* | Bglap, Bglap2, Bglap3 | Alliance of Genome Resources | ||||
| osteoporosis | BMP2* | Bmp2 | Alliance of Genome Resources | ||||
| osteoporosis | CALCA* | Calca | Alliance of Genome Resources | ||||
| osteoporosis | CALCR* | Calcr | Alliance of Genome Resources | ||||
| osteoporosis | COL1A1* | Col1a1 | Alliance of Genome Resources | ||||
| osteoporosis | COL1A2* | Col1a2 | Alliance of Genome Resources | ||||
| osteoporosis | CXCR4* | Cxcr4 | Alliance of Genome Resources | ||||
| osteoporosis | CYP17A1* | Cyp17a1 | Alliance of Genome Resources | ||||
| osteoporosis | CYP19A1* | Cyp19a1 | Alliance of Genome Resources | ||||
| osteoporosis | DBP* | Dbp | Alliance of Genome Resources | ||||
| osteoporosis | ESR1* | Esr1 | Alliance of Genome Resources | ||||
| osteoporosis | ESR2* | Esr2 | Alliance of Genome Resources | ||||
| osteoporosis | GSTP1* | Gstp1, Gstp2, Gstp3 | Alliance of Genome Resources | ||||
| osteoporosis | IGF1R* | Igf1r | Alliance of Genome Resources | ||||
| osteoporosis | IL1A* | Il1a | Alliance of Genome Resources | ||||
| osteoporosis | IL1RN* | Il1rn | Alliance of Genome Resources | ||||
| osteoporosis | IL32* | ||||||
| osteoporosis | LEP* | Lep | Alliance of Genome Resources | ||||
| osteoporosis | LEPR* | Lepr | Alliance of Genome Resources | ||||
| osteoporosis | LRP5* | Lrp5 | Alliance of Genome Resources | ||||
| osteoporosis | PDLIM4* | Pdlim4 | Alliance of Genome Resources | ||||
| osteoporosis | SOD2* | Sod2 | Alliance of Genome Resources | ||||
| osteoporosis | TNFRSF1B* | Tnfrsf1b | Alliance of Genome Resources | ||||
| osteoporosis | TNFRSF11A* | Tnfrsf11a | Alliance of Genome Resources | ||||
| Paget's disease of bone | OPTN* | Optn | Alliance of Genome Resources | ||||
| Paget's disease of bone | TNFRSF11B* | Tnfrsf11b | Alliance of Genome Resources | ||||
| Paget's disease of bone | VCP* | Vcp | Alliance of Genome Resources | ||||
| Paget's disease of bone 2 | TNFRSF11A* | Tnfrsf11a | Alliance of Genome Resources | ||||
| Paget's disease of bone 3 | SQSTM1* | Sqstm1 | Alliance of Genome Resources | ||||
| Paget's disease of bone 5 | TNFRSF11B* | Tnfrsf11b | Alliance of Genome Resources | ||||
| Paget's disease of bone 6 | ZNF687* | Zfp687 | Alliance of Genome Resources | ||||
| sclerosteosis | SOST* | Sost | Alliance of Genome Resources | ||||
| Worth syndrome | LRP5* | Lrp5 | Alliance of Genome Resources | ||||
| X-linked recessive hypophosphatemic rickets | CLCN5* | Clcn5 | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| autosomal dominant hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack | 1 model | |
| autosomal recessive hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack | 1 model | |
| osteoporosis | Tg(APCS-Tnfsf11*)#aKhs | 1 model | |
| osteoporosis | Tg(CD4-CIITA)357Ccum | 1 model | |
| osteoporosis | Tg(TNFSF11)5519Edou | 1 model | |
| SOST-related sclerosing bone dysplasia | Tg(RP11-209M4)AGglo | 2 models | |
| SOST-related sclerosing bone dysplasia | Rr20 | 1 model | |
| X-linked hypophosphatemic rickets | Tg(Col1a1-FGF2*,-Sapphire)203Mmh | 1 model | |
| X-linked hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack | 1 model | |