Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
hm1
hm2
cn3
cx4
cx5
cx6
cx7
cx8
cx9
show or hide all annotated terms Sex:
                 
cardiovascular system
√
phlebitis
√
cellular
√ √
abnormal T cell proliferation
√
increased T cell proliferation
√
digestive/alimentary system
√
abnormal salivary gland morphology
√
salivary gland inflammation
√
endocrine/exocrine glands
√ √
abnormal salivary gland morphology
√
salivary gland inflammation
√
thymus hypoplasia
√ √
pancreas fibrosis
√
pancreas inflammation
√
growth/size/body
√
decreased body weight
√
enlarged spleen
√
increased spleen weight
√
spleen hyperplasia
√
hematopoietic system
√ √ √ √ √ √ √ √
abnormal T cell proliferation
√
increased T cell proliferation
√
thymus hypoplasia
√ √
enlarged spleen
√
increased spleen weight
√
spleen hyperplasia
√
increased susceptibility to autoimmune hemolytic anemia
√
increased eosinophil cell number
√
abnormal lymphocyte morphology
√
abnormal T cell selection
√
decreased double-positive T cell number
√
abnormal gamma-delta T cell differentiation
√
arrested T cell differentiation
√
increased B cell number
√
increased plasma cell number
√
abnormal T cell subpopulation ratio
√
absent CD4-positive, alpha-beta T cells
√ √
increased CD4-positive, alpha-beta T cell number
√
increased T-helper 2 cell number
√
absent CD8-positive, alpha-beta T cells
√ √
increased memory T cell number
√
decreased regulatory T cell number
√
increased spleen germinal center number
√
abnormal spleen periarteriolar lymphoid sheath morphology
√
abnormal B cell activation
√
increased IgE level
√
increased IgG1 level
√
increased IgM level
√
abnormal T-helper 2 physiology
√ √ √ √
abnormal regulatory T cell physiology
√
decreased platelet aggregation
√
abnormal platelet dense granule physiology
√
homeostasis/metabolism
√ √
decreased platelet aggregation
√
abnormal platelet dense granule physiology
√
increased blood urea nitrogen level
√
albuminuria
√
immune system
√ √ √ √ √ √ √ √
immune system phenotype
N N
abnormal T cell proliferation
√
increased T cell proliferation
√
increased susceptibility to autoimmune hemolytic anemia
√
abnormal B cell activation
√
abnormal T-helper 2 physiology
√ √ √ √
abnormal regulatory T cell physiology
√
abnormal immune system morphology
√
increased eosinophil cell number
√
abnormal lymphocyte morphology
√
abnormal T cell selection
√
decreased double-positive T cell number
√
abnormal gamma-delta T cell differentiation
√
arrested T cell differentiation
√
increased B cell number
√
increased plasma cell number
√
abnormal T cell subpopulation ratio
√
absent CD4-positive, alpha-beta T cells
√ √
increased CD4-positive, alpha-beta T cell number
√
increased T-helper 2 cell number
√
absent CD8-positive, alpha-beta T cells
√ √
increased memory T cell number
√
decreased regulatory T cell number
√
abnormal immune system organ morphology
√
thymus hypoplasia
√ √
enlarged spleen
√
increased spleen weight
√
spleen hyperplasia
√
increased spleen germinal center number
√
abnormal spleen periarteriolar lymphoid sheath morphology
√
abnormal lymph node secondary follicle morphology
√
abnormal lymph node germinal center morphology
√
enlarged lymph nodes
√
abnormal immune serum protein physiology
√
increased IgE level
√
increased IgG1 level
√
increased IgM level
√
increased interferon-gamma secretion
√
increased interleukin-4 secretion
√
increased anti-erythrocyte antigen antibody level
√
increased anti-nuclear antigen antibody level
√
increased anti-chromatin antibody level
√
chronic inflammation
√
increased inflammatory response
√
phlebitis
√
salivary gland inflammation
√
pancreas inflammation
√
liver inflammation
√
kidney inflammation
√
glomerulonephritis
√
lung inflammation
√
liver/biliary system
√
liver inflammation
√
renal/urinary system
√
albuminuria
√
kidney inflammation
√
glomerulonephritis
√
renal glomerular immunoglobulin deposits
√
renal fibrosis
√
respiratory system
√
lung inflammation
√